Abstract 13207: Associations of the Ankle Brachial Index With Functional Performance Varies Between Participants With Vs. Without Diabetes Mellitus
Background The ankle brachial index (ABI) is moderately associated with the degree of functional impairment in populations of people with and without peripheral arterial disease (PAD). It is unknown whether the association of the ABI with functional performance differs between diabetic and non-diabetic persons with PAD. The association may differ between individuals with vs. without diabetes mellitus, if the ABI is less accurate in estimating PAD severity in individuals with diabetes mellitus.
Methods Participants were 1113 men and women with and without PAD identified from Chicago-area medical centers. Measurements included ABI, diabetic status (diabetic vs. non-diabetic), accelerometer-measured physical activity over 7 days, 6-minute walk, 4 meter walking velocity (usual and fast paced). Associations of the ABI with functional performance were evaluated among participants with vs. without diabetes mellitus, adjusting for age, sex, race, BMI, smoking history, and comorbidities. Interaction tests were performed for the presence vs. absence of diabetes on the association of ABI with each functional outcome.
Results Please refer to Table 1 for results. An interaction test for the presence of diabetes on the association of ABI and functional outcomes was significant for accelerometer-measured physical activity (p = 0.02) but not for the other functional outcome measures.
Conclusions Our results suggest that lower ABI values are associated with poorer six-minute walk performance among participants with and without diabetes mellitus. Associations of the ABI with four-meter walking velocity appear to be stronger among participants without diabetes mellitus, compared to those with diabetes. However, a significant interaction for the presence of diabetes mellitus on the association of ABI and functional performance was identified only for the association of the ABI with physical activity levels.
- © 2011 by American Heart Association, Inc.