Abstract 13157: Exercise is Associated With a Significant Reduction in Peripheral Vascular Disease in a Self Referred Population of Over 3.8 Million Us Adults
Data regarding the role of exercise in the prevention of peripheral artery disease (PAD) and carotid artery disease (CarAD) is less robust than for coronary artery disease.
This study analyzed a database of 3,896,778 people in the US (63.7+10.6yrs, 62.3% female) who underwent screening ankle brachial index (ABI) and carotid duplex ultrasound studies in response to advertisement from 2003 to 2008. Collected information included demographics, exercise history, cardiovascular risk factors and symptom information. We report the relationship between use of exercise, exercise frequency and type of exercise (versus no exercise) with PAD (ABI<0.9), CarAD (>50% stenosis of the internal carotid artery), and any peripheral vascular disease (PVD; PAD and/or CarAD). Prevalence of Any PVD, PAD, or CarAD is presented with unadjusted and with multivariate adjusted logistic regression analysis.
Any exercise was associated with a significant and clinically important reduction in the prevalence of PVD, PAD and CarAD as compared with patients who reported no exercise. (Table) Increasing frequency of exercise was associated with a lower prevalence of any PVD; 1x/week OR 0.765, 2x/week OR 0.708, 3x/week OR 0.662, and ≥4x/week OR 0.635; P<0.001 for trend). The association of exercise frequency with prevalence of PVD was most evident for PAD. Among all the different types of exercise reported (running, swimming, tennis, bicycling, walking, and other), running had the lowest odds ratio of any PVD (OR .501, 95% CI 0.483 to 0.520).
The results of this study demonstrate a significant association between regular physical exercise and a decreased risk of peripheral vascular disease in several vascular territories. Increasing exercise frequency was associated with the greatest reduction in vascular disease.
- © 2011 by American Heart Association, Inc.