Abstract 13137: Vitamin D Levels in People with Peripheral Arterial Disease and Associations with Functional, Muscle, and Nerve Outcomes
BACKGROUND. We assessed associations of vitamin D levels with functional performance, calf muscle density, and peripheral nerve function in participants with lower extremity peripheral arterial disease (PAD)
METHODS. Participants were 413 men and women with an ankle brachial index (ABI) < 0.90 who underwent measurement of 25-hydroxy vitamin D (Diasorin radioimmunoassay method) along with six-minute walk testing, computed tomography-measured calf muscle density, and nerve conduction velocity (NCV). Associations of vitamin D levels with study outcomes were analyzed adjusting for age, sex, and race (Model 1). Analyses were repeated with additional adjustment for ABI, body mass index, smoking, and comorbidities (Model 2).
RESULTS. Of the 413 PAD participants, 54 (13.1%) had a vitamin D level < 25 nmols and 116 (28.1%) had a level < 37.5 nmols. Table 1 shows associations of vitamin D levels with study outcomes. In addition, lower vitamin D levels were associated with poorer sural NCV (P=0.036) but not with poorer ulnar NCV (P=0.125).
CONCLUSIONS. Low levels of vitamin D are common in men and women with PAD. Adjusting for covariates including comorbidities, BMI, and the ABI, we found no significant associations of lower vitamin D levels with poorer functional performance or calf muscle measurements. Associations of low vitamin D levels with poorer peripheral nerve function require further study.
- © 2011 by American Heart Association, Inc.