Abstract 13126: Physical Activity and Cardiovascular Events in the Multi-Ethnic Study of Atherosclerosis (MESA)
BACKGROUND: Physical activity improves cardiovascular health. We examine the associations between physical activity and incident cardiovascular events.
METHODS: 6691 members of a multi-ethnic cohort, the Multi-Ethnic Study of Atherosclerosis (MESA) aged 45-84 years (47% female) and free of clinically apparent cardiovascular disease (CVD), completed a standard questionnaire about physical activity (PA) patterns in the prior month. Intentional (sports and conditioning) exercise, total moderate and vigorous physical activity (MVPA) and vigorous PA levels were evaluated as metabolic equivalent minutes per week (MET-min/week) (600 MET-min ≈ 150 minutes of moderate intensity aerobic activity). Cox proportional hazard models were constructed to predict the end points of cardiovascular disease (CVD), coronary heart disease (CHD), cerebrovascular disease (stroke or transient ischemic attack) and for heart failure after adjustment for traditional cardiovascular risk factors.
RESULTS: A total of 415 participants with incident CVD events (302 CHDs, 147 cerebrovascular diseases, 148 heart failure) were observed during a mean follow-up of 6.1 years. In adjusted models, intentional exercise and vigorous PA were associated with a lower risk of CVD events (hazard ratio [HR]: 0.97 per 600 met-min/week, p=0.02 and p=0.03, respectively) whereas, MVPA was not significantly associated with CVD events. Intentional exercise and vigorous PA were marginally associated with CHD (HR = 0.97 with p=0.11 and HR = 0.97 with p=0.07 respectively). No significant associations were seen for the endpoints of cerebrovascular disease and for heart failure.
CONCLUSIONS: These data indicate a beneficial independent association of small magnitude of intentional exercise and vigorous PA with CVD events in a multi-ethnic population. Moderate levels of physical activity were not associated with incident cardiovascular events.
- © 2011 by American Heart Association, Inc.