Abstract 13120: Hypertrophic Cardiomyopathy with Longevity into the Tenth Decade of Life
Background. Hypertrophic cardiomyopathy (HCM) is the most common cause of sudden death in the young, but survival to particularly advanced age is less well appreciated.
Methods. We report the prevalence, clinical features and demographics of HCM patients surviving to the age of 90 years or older, identified by interrogation of the HCM Center database (Minneapolis Heart Institute Foundation).
Results. Of the 1297 HCM patients, 26 (2.0%) had achieved the age of at least 90 years; 18 (69%) were women. Age at HCM diagnosis was 61 to 92 years (≥75 years in 21), with disease recognition under fortuitous circumstances by detection of a heart murmur or during family screening (n = 6), or after onset of new symptoms (n = 20). At most recent evaluation (or death) patients were 90.0 to 96.7 years of age (mean 92.2 ± 2), with 6 presently alive at 90 to 96 years of age; HCM did not appear to be the primary cause of demise in any patient. Maximum LV wall thicknesses were 15-31 mm (mean 20 ± 3 mm); 8 patients (31%) had obstruction to LV outflow at rest (gradients, 38-135 mmHg). HCM-related complications occurred in18 patients (69%), including heart failure symptoms, atrial fibrillation, and non-fatal embolic stroke. Although no patient died suddenly, 13 (50 %) nevertheless carried conventional HCM markers of risk. A greater proportion of patients in this cohort reached ≥ 90 years of age (2.0%) than expected in the general population (0.8%; p < 0.001).
Conclusions. HCM is consistent with survival to normal life expectancy, including particularly advanced age into the tenth decade of life, with demise ultimately largely unrelated to this disease. This principle regarding the natural history of HCM can afford a measure of reassurance to many patients.
- © 2011 by American Heart Association, Inc.