Abstract 13044: Application of Speckle Tracking to Cardiac Magnetic Resonance Imaging for Quantifying Ventricular Mechanics of Single Ventricle Patients from the Pediatric Heart Network Study
Background: Speckle tracking analysis can be applied to cardiac magnetic resonance images (MRI), allowing quantitation of functional mechanics such as strain, velocity, strain rate, and displacement. Single ventricle patients undergo palliative surgeries such as the Fontan procedure, but are difficult to follow clinically for signs of improvement with new medications or for decreased ventricular function.
Methods: The Fontan Cross-Sectional Study was designed by the Pediatric Heart Network and funded by the National Heart, Lung and Blood Institute to collect information regarding the relationship between subjective health status and clinical measures in post-Fontan patients. Patients at seven pediatric cardiac centers in the United States ages 6-18 years of age were enrolled, having had a Fontan procedure greater than or equal to 6 months prior to initial testing. Short axis and long axis views from gradient echo cine cardiac MRIs of 129 of these patients were analyzed using a Siemens Velocity Vector Imaging analysis program, with results compared to 4 normal patients.
Results: Patients were categorized as one of three ventricular types: left ventricular (LV), right ventricular (RV), and mixed. The averages and standard deviations of values for these groups were compared to averages and standard deviations of normal patients. Although values differed between normal and single ventricle patients in strain, velocity, and strain rate, no overlap of standard deviations was seen only in displacement data measured from the long axis. LV (1.75, 2.99) RV (1.56, 2.98), and mixed (1.80, 2.74) longitudinal and radial displacement values respectively were markedly smaller than normal (4.07, 5.17).
Conclusions: Speckle tracking analysis applied to cardiac MRI images of single ventricle patients quantifies important differences in ventricular mechanics in single ventricle patients compared to normal controls.
- © 2011 by American Heart Association, Inc.