Abstract 12984: Long Term Impact of New Onset Post Operative Atrial Fibrillation on Mortality After Single Isolated Coronary Artery Bypass Graft Surgery
Introduction Post-operative atrial fibrillation (POAF) is a common rhythm disturbance after coronary artery bypass graft surgery (CABG) that prolongs in-hospital stay. This study investigated the independent effect of POAF on long term mortality after CABG.
Methods We identified 3637 patients, age > 18 years who underwent primary isolated CABG between 1993 and 2001. Patients were identified using the Cardiovascular Information Registry (CVIR) that contains detailed demographic, clinical, pathologic, operative, and outcome variables on all patients undergoing cardiac surgery at Cleveland Clinic, abstracted from clinical records concurrent with patient care. The cumulative incidence of mortality was given by Kaplan-Meier estimates and groups were compared using adjusted hazard ratios (HR) generated from Cox proportional hazard models.
Results The mean age was 64 ± 5 yrs old and 29 % were female. During the index hospital stay POAF was documented in 1104 patients (30.3 %) and were followed up for a median of 8 years. The presence of POAF, using adjusted multivariate cox proportional hazard analysis demonstrated POAF was an independent predictor of overall mortality with a HR 1.23 (95 % confidence interval (1.01-1.49), P =0.039) shown in Table 1 and Figure 1.
Conclusions POAF is an independent predictor of overall and late mortality after isolated coronary artery bypass graft surgery. The causative role of POAF on long term mortality and the identification of unmeasured variables that contribute to this observation deserve further exploration.
- © 2011 by American Heart Association, Inc.