Abstract 12972: Serum Levels of Advanced Glycation End Products (AGEs) Are Independent Correlates of Vascular Inflammation Evaluated by 18F-Fluorodeoxyglucose Positron Emission Tomography (FDG-PET) in Humans
Background: Advanced glycation end products (AGEs) evoke inflammatory reactions, thus contributing to the development and progression of atherosclerosis.
Objectives: We investigated the relationship between serum levels of AGEs and vascular inflammation within the atherosclerotic plaques in humans.
Methods: The study involved 275 consecutive outpatients (189 males and 86 females; mean age 61.2±8.8 years) who underwent a complete history and physical examination, determinations of blood chemistries, anthropometric and metabolic variables, including AGEs. Serum AGE levels were examined with an enzyme-linked immunosorbent assay. Vascular [18F]-fluorodeoxyglucose (FDG) uptake, an index of vascular inflammation, was measured as blood-normalized standardized uptake value, known as the target-to-background ratio (TBR) by FDG-positron emission tomography (FDG-PET).
Results: In univariate analyses, a statistical significance and a dose-response relationship were demonstrated between TBR and body mass index (BMI), waist circumference, carotid intima-media thickness (IMT), blood pressure, or AGEs. Multiple stepwise regression analysis revealed significant associations between TBR and AGEs (p<0.001), carotid IMT (p<0.01), or BMI (p<0.02). When age- and sex-adjusted TBR values stratified by AGE tertiles were compared using ANCOVA, a significant trend was observed (p<0.01).
Conclusions: The present study reveals that serum levels of AGEs are independently associated with vascular inflammation evaluated by FDG-PET, thus suggesting that serum AGEs levels may be a biomarker that could reflect vascular inflammation within the atherosclerotic plaques in humans.
- © 2011 by American Heart Association, Inc.