Abstract 12918: Adipose Tissue Depots and Their Cross-Sectional Association With Circulating Biomarkers of Metabolic Regulation
Introduction: Several circulating biomarkers have been associated with downstream metabolic and atherogenic consequences. In addition, body fat distribution is associated with cardiovascular disease (CVD) and its risk factors. Secretion of biomarkers from adipose tissue or the liver may contribute to a potential role of specific fat depots in cardiometabolic disease.
Methods: Participants from the Framingham Heart Study (n=1583, 47% women, mean age 45 years) underwent volumetric assessment of subcutaneous (SAT) and visceral adipose tissue (VAT) by multidetector computed tomography. We measured a panel of circulating biomarkers secreted by adipose tissue or liver (leptin, leptin receptor, fatty acid binding protein-4 [FABP-4], fetuin-A, retinol binding protein-4 [RBP-4]). Using multivariable linear regressions adjusted for age, alcohol use, smoking, menopausal status (among women), and hormone therapy (among women),we examined the relations of SAT and VAT with natural log-transformed biomarker concentrations in blood.
Results: After multivariable adjustment, both SAT and VAT were positively associated with circulating leptin, FABP-4, fetuin-A and RBP-4 levels and negatively associated with leptin receptor concentrations in both sexes. Results were consistently stronger in women as compared to men, particularly for leptin (with SAT and VAT) and FABP-4 (with VAT) (sex interactions p<0.0001). In multivariable models adjusted for body mass index, both SAT and VAT remained associated with leptin, leptin receptor and FABP-4, and VAT with RBP-4. VAT additionally remained associated with all biomarkers after adjustment for SAT. In contrast, the association of SAT with fetuin-A and RBP-4 was no longer significant after VAT adjustment.
Conclusion: Both SAT and VAT were associated with multiple biomarkers secreted by adipose tissue or the liver, and most associations persist after adjusting for generalized adiposity. VAT remains associated with all biomarkers despite adjustment for SAT. These findings suggest a mechanism by which specific fat depots might contribute to metabolic dysregulation.
- © 2011 by American Heart Association, Inc.