Abstract 12888: Tissue Characterization of Coronary Plaque in Patients With Renal Dysfunction
Background: It is well known that chronic kidney disease is a risk factor for ischemic heart disease. Integrated backscatter intravascular ultrasound (IB-IVUS) facilitates to assess the tissue characterization of coronary plaque composition. Recently it has been found that lipid-rich plaque detected by IB-IVUS is associated with vulnerable plaque. The aim of this study was to identify relationship between estimated glomerular filtration rate (eGFR) and coronary plaque characteristics using IB-IVUS.
Methods: IB-IVUS was performed in 190 consecutive patients who underwent percutaneous coronary intervention (PCI) due to coronary artery disease. We divided them into three groups according to eGFR. (group 1; eGFR ≥ 90ml/min/1.73m2, group 2; 60 ≤ eGFR < 90ml/min/1.73m2, group 3; eGFR < 60ml/min/1.73m2). We evaluated tissue characterization of plaque in non-culprit lesion by 3-dimensional analyses using IB-IVUS.
Results: The number of patients in groups 1, 2, and 3 was 19, 118, and 53, respectively. Baseline clinical characteristics were similar among 3 groups except for higher age and higher prevalence of male gender in group 3. IB-IVUS showed that %lipid volume was 44.9 ± 5.0% in group 1, 53.6 ± 6.3% in group 2, and 63.6 ± 6.4% in group 3, respectively (P < 0.01) and that %fibrous volume was 53.7 ± 4.9% in group 1, 45.1 ± 6.0% in group 2, and 35.3±6.3% in group 3, respectively (P < 0.01). eGFR levels were significantly moderately correlated with %lipid volume and with %fibrous volume in coronary plaques (r = -0.67, p<0.001, and r = 0.67, p<0.001, respectively). Even after adjustment of coronary risk factors, a low eGFR was independently associated with an increased %lipid volume and a decreased %fibrous volume.
Conclusion: Lower eGFR levels were associated with higher lipid volume and lower fibrous volume, contributing to the vulnerability of coronary plaque.
- © 2011 by American Heart Association, Inc.