Abstract 12863: Sex Differences for Heart Failure Patients with Preserved and Reduced Systolic Function: Data from the American Heart Association Get With the Guidelines-Heart Failure
Objectives: We sought to evaluate sex differences in baseline characteristics, in-hospital mortality, and risk factors (RF) for survival in hospitalized HF patients with preserved and reduced ejection fraction (EF).
Background: To date there are no sex specific survival comparisons between preserved and reduced EF HF patients. Large registries noting sex differences did not separate HF patient by EF and those that compared preserved and reduced EF did not provide sex specific data.
Methods: We included HF patients from hospitals participating in GWTG-HF with preserved (LVEF≥ 50%) or reduced (LVEF <40%) EF. The primary endpoint was in-hospital mortality. Multivariate GEE logistic models were used to compute ORs accounting for hospital clustering.
Results: The cohort consisted of 37,699 HF patients with EF ≥50% [65% female (F), 35% male (M)] and 51,428 HF patients with EF <40% (36% F, 64% M). Women compared to men with preserved and reduced EF were older and more likely to have hypertension, and valvular heart disease and less likely to have coronary artery disease or renal insufficiency. There were no sex differences in in-hospital mortality (EF >50%, 2.61% F vs. 2.62% M, p=0.96; EF <40%, 2.69% F vs. 2.89% M, p=0.20) and many RF such as age, systolic blood pressure (SBP), heart rate (HR), and history of renal failure (RF)/dialysis were highly predictive of death for all subgroups (Table 1).
Conclusions: In a large registry we found that despite differences in baseline characteristics, women and men with preserved and reduced EF have similar in-hospital mortality and risk factors predicting death.
- © 2011 by American Heart Association, Inc.