Abstract 12758: Normal Values of Left Ventricular Regional Myocardial Deformation Measured by Two-Dimensional Speckle-Tracking Echocardiography: A Multicenter Study
Background: Although two-dimensional speckle-tracking echocardiography (STE) has been validated in animal experiments for quantitative evaluation of myocardial deformation, clinically applicable normal reference data from large healthy population is lacking.
Methods: In this multicenter study, 228 healthy volunteers (109 males, mean age 44±5, range 18-78 years) without evidence of cardiovascular disease were examined by STE to assess left ventricular (LV) longitudinal (LS), circumferential (CS) and radial (RS) strain. In 52 subjects, the reproducibility and agreement of strain measurement between machines were assessed using GE Vivid7 and Phillip iE33.
Results: Normal values of STE were shown in Table. Overall, LS and CS increased while RS decreased from the LV base to apex (p<.01). With advancing age, LS progressively decreased (r=-0.2, p<.02), but CS paradoxically increased (r=0.3, p<.01), suggestive of a normal compensatory mechanism. RS showed no age dependency. The agreement of strain measurement between equipment of two companies are acceptable (average difference of global LS was 2.2±2.2%, correlation r=0.74). Inter- and intra-observer measurement variability was acceptable (intra and inter average difference of global LS was 0.8 ±2.1% and 0.9±2.4%, correlation r=0.82 and 0.79 respectively).
Conclusions: This study provides normal reference range of LV speckle strain measured by 2D STE in healthy adults, which will be useful for future clinical application and research. The measurement of RS has the advantage of being age-independent.
- © 2011 by American Heart Association, Inc.