Abstract 12754: Prevalence and Risk Factors of Carotid Vessel Wall Inflammation in Coronary Artery Disease Patients: An 18F-FDG PET / CT Imaging Study
Objective: Inflammation is increasingly being perceived as a pivotal process in atherogenesis. We investigated the prevalence and clinical risk factors of carotid vessel wall inflammation by means of 18F-fluorodeoxyglucose positron emission tomography (FDG-PET) in a population consisting of coronary artery disease (CAD) patients.
Methods: Carotid inflammation was quantified in 82 CAD patients (age 62±10 years) as the maximum target-to-background ratio (wholevesselTBRmax). Furthermore, we assessed the maximal standardized uptake value values (wholevesselSUVmax), the single hottest segment (SHS), and the percent active segments (PAS) of the FDG uptake in the artery wall, measured by FDG-PET.
Results: Whole vessel TBRmax >1.8 was present in 67%, >2.0 in 39%, >2.2 in 23%, and >2.4 in 12% of the population. Multiple linear regression analysis with backward elimination revealed that body mass index (BMI) ≥30 kg/m2 (p65 years (p=0.01), smoking (p=0.02), and hypertension (p=0.01) were associated with wholevesselTBRmax, The number of components of the metabolic syndrome was also associated with wholevesselTBRmax (p=0.02). In similar analyses wholevesselSUVmax was associated with BMI ≥30 kg/m2 (p65 years (p=0.004), male gender (p=0.02), and hypertension (p=0.04); SHS with BMI ≥30 kg/m2 (p<0.0001), age >65 years (p=0.02), smoking (p=0.04), and hypertension (p=0.05); PAS with BMI ≥30 kg/m2 (p=0.001), smoking (p=0.03), and hypertension (p=0.01).
Conclusions: Carotid inflammation as revealed by FDG-PET is highly prevalent in the CAD population and is associated with obesity, age over 65 years, history of hypertension, smoking, and male gender. Artery wall FDG uptake increased with clustering of components of the metabolic syndrome.
- © 2011 by American Heart Association, Inc.