Abstract 12752: Epicardial Adipose Tissue Volume: Relationship With Glycaemic State and Coronary Artery Disease in Patients Presenting With Stable Chest Pain
Introduction: Epicardial adipose tissue (EAT) volume has been associated with coronary artery disease (CAD). As both impaired fasting glucose (IFG) and diabetes mellitus type 2 (DM2) patients have higher EAT volumes, it is suggestive that EAT may play a role in the accelerated CAD process in these patients. Aim of this study was to examine the relation between EAT, glycaemic state and CAD in patients presenting with stable chest pain.
Methods: In 410 stable chest pain patients, cardiac computed tomographic angiography (CCTA) assessed presence of CAD. Calcium score was used to determine extent of CAD. EAT volume was measured using 3-dimensial quantification. Fasting glucose was measured and traditional risk factors were recorded.
Results: 410 patients (57±11 years, 49% male) consisted of 83 DM2, 118 IFG and 209 controls. DM2 as well as IFG patients had higher EAT volumes when compared to controls (98±41, 92±39 and 75±34 cm³, respectively, p<0.001). EAT predicted for the presence of CAD (OR 1.01, p<0.001) and extent of CAD (B 0.6, p<0.009). DM2 also predicted for the presence of CAD (OR 2.38, p=0.003) and extent of CAD (B 96, p<0.001). In a multivariable regression model corrected for traditional risk factors, DM2 independently predicted for the extent of CAD (B 73, p=0.002), EAT did not (B -0.11, p=0.68).
Conclusion: Although both EAT and DM2 were associated with CAD, EAT was not an independent predictor. Therefore, DM2 as well as other traditional risk factors outweighed EAT measurement as a clinical risk factor to predict for CAD in stable chest pain patients.
- © 2011 by American Heart Association, Inc.