Abstract 12708: Determinants of Epicardial Adipose Tissue Patients With Coronary Artery Disease
Introduction: Recent studies have shown a significant association between epicardial adipose tissue (EAT) and the presence and extent of coronary artery disease (CAD). Purpose: Our aim was to assess the determinants of EAT in patients with CAD.
Methods: 200 consecutive patients with proven CAD underwent late gadolinium enhancement (LGE) cardiac magnetic resonance (CMR) examination. Several CMR parameters and the extent of myocardial scarring assessed by LGE were determined and correlated to the amount of EAT expressed as mass indexed to body surface area.
Results: In the whole study cohort EAT mass ranged 11 g/m² to 68 g/m² with a mean of 28±10 g/m² and was significantly correlated to body mass index (BMI) (p=0.03), atrial fibrillation (p=0.02) as well as the following CMR parameters: left ventricular function (LV-F) (p<0.0001), LV enddiastolic volume index (LV-EDVI) (p=0.02), LV systolic volume index (LV-ESVI) (p=0.001), LV enddiastolic diameter (LV-EDD) (p=0.0004), LVRI (p<0.0001), and the LGE extent expressed as % of LV mass (p<0.0001). Of these parameters LVF (p=0.002), BMI (p=0.005) and LV-EDD (p=0.01) remained significantly associated with EAT in a multivariable linear regression model. Interestingly, subgroup analysis with regard to symptoms showed that in asymptomatic (NYHA class I, Figure A1-A2) patients only the BMI (p=0.01) was an independent predictor of EAT. Whereas, in symptomatic patients (NYHA class II-IV, Figure B1-B2), EAT correlated not only to the LV-EDM (p<0.0001), but also to the LVF (p=0.001).
Conclusion: Determinants of EAT could be identified in CAD patients. Additionally, we could show that they were different dependent on the NYHA classification and that the EAT mass differed signifiantly in asymptomatic (NYHA I ) and symptomatic patients (NYHA II-IV, Figure C).
- © 2011 by American Heart Association, Inc.