Abstract 12665: Usefulness of Myocardial Perfusion Imaging With 256 Multislice Computed Tomography in Myocardial Infarction
Purpose:We sought to identify viable myocardium and coronary vessel with 256 multislice CT (MSCT) in myocardial infarction (MI) patients.
Methods: 25 consecutive anterior MI patients with successful primary percutaneous coronary intervention underwent MSCT at 10 days after MI onset. Perfusion images were interpreted using 17 segment AHA model and analyzed using a semi-automated approach to define the regional signal density (SD) for each vascular territory. The SD in the myocardium was measured at diastole of first pass imaging and delayed myocardial imaging 2 minutes later injection of contrast media.
Results: The SD of the infarct myocardium in the first pass is lower than that of the remote myocardium (99.2±10 vs. 126.2±10 HU, p<0.01). In the delayed imaging the SD is not significant difference between the infarct and remote myocardium (96.4±7 vs. 93.8±7 HU). Only in the infarct area, delayed enhance region was identified. The peak serum level of creatine kinase significantly correlated with the change of SD (SD in first pass_SD in delayed imaging) in the infarct region (R=-0.78, p<0.01).
Conclusion: The spatial extent of myocardial infarction can be determined and quantified accurately with contrast-enhanced MSCT. High-resolution MSCT coronary angiography combined with perfusion imaging enables assessment of both coronary images and myocardial viability and may promise to be a single imaging modality for the comprehensive assessment of cardiovascular disease.
- © 2011 by American Heart Association, Inc.