Abstract 12638: Serum Low-density Lipoprotein to High-density Lipoprotein Ratio is a Potential Indicator For Reduction of Renal Damage Progression in Patients With Acute Myocardial Infarction
Introduction: Statin therapy improves serum cholesterol levels and reduces the progression of renal damage. Serum low-density lipoprotein to high-density lipoprotein ratio (L/H) is a useful indicator of the lipid control for suppression of coronary plaque enhancement and the secondary prevention of cardiac events in patients with ischemic heart disease.
Hypothesis: We assessed the hypothesis that statin therapy guided by L/H reduces the progression of renal damage in acute myocardial infarction (AMI) patients.
Method: From April 2006 to March 2010, a total of 190 consecutive AMI patients were enrolled in this study. All patients had undergone primary stenting and received atorvastatin within 24 hours after AMI onset. We allocated enrolled patients to two groups according to their L/H at 6 months after AMI onset: L/H < 2 group (n = 109) and L/H ≥ 2 group (n = 81). We compared the change rates of serum creatinine (sCr) level, estimated glomerular filtration rate (eGFR), and serum cholesterol level between the two groups. In addition, we conducted multivariate analysis about the causal association between the change rates of sCr level and serum cholesterol level in all patients.
Results: The sCr change rate at 1 month in the L/H < 2 group tended to be lesser (mean [%] ± SE, 9.19 ± 2.05 vs. 13.6 ± 2.55; p = 0.09) and the eGFR change rate at 1 month in the L/H < 2 group tended to be greater (−1.84 ± 4.43 vs. −9.38 ± 2.11; p = 0.06) than in the L/H ≥ 2 group. The sCr change rate at 6 months in the L/H < 2 group was significantly lesser (9.79 ± 2.23 vs. 16.5 ± 2.77; p < 0.05) and the eGFR change rate at 6 months in the L/H < 2 group was significantly greater (−2.75 ± 3.85 vs. −11.8 ± 1.93; p < 0.05) than in the L/H ≥ 2 group. Furthermore, the change rates of sCr level and high-density lipoprotein level were negatively correlated (r = −0.560; p < 0.05).
Conclusion: Statin therapy to keep the L/H under 2 might be useful for reduction of renal damage progression in patients with acute myocardial infarction.
- © 2011 by American Heart Association, Inc.