Abstract 12631: The Mode of Death in Implantable Cardioverter Defibrillator Recipients: Results in Routine Clinical Practice
Introduction: Large randomized trials have demonstrated a beneficial effect on the mortality rate of selected patients following implantable cardioverter defibrillator (ICD) implantation. Although this resulted in the widespread acceptance of ICD therapy as an effective treatment strategy, mortality events of ICD recipients in routine clinical practice have scarcely been examined.
Objective: To assess the mode of death in primary and secondary prevention ICD recipients in routine clinical practice.
Methods: All patients who underwent primary or secondary prevention ICD implantation at the Leiden University Medical Center in the period 1996-2010 were included in the analysis. In patients who died during follow-up, the mode of death was retrieved from hospital and GP records, and categorized according to a predetermined classification by experts' opinion. In the current analysis, the mode of death was classified as: heart failure death, sudden death, other death, and unknown death.
Results: A total of 3142 patients, 1937 (62%) primary and 1205 (38%) secondary prevention ICD recipients, were included in the analysis. During follow-up, 351 (51%) primary and 342 (49%) secondary ICD recipients died. Mode of death in primary prevention ICD recipients was as follows: 143 (41%) heart failure deaths, 20 (6%) sudden deaths, 136 (39%) other deaths, and 52 (15%) unknown deaths. In secondary prevention ICD recipients, mode of death was as follows: 109 (32%) heart failure deaths, 22 (6%) sudden deaths, 142 (42%) other deaths, and 69 (20%) unknown deaths.
Conclusion: A substantial part of primary and secondary ICD recipients die as a result of heart failure. Similar sudden death rates (6%) were observed for both groups.
- © 2011 by American Heart Association, Inc.