Abstract 12584: Tetranectin is Associated with Cardiac Allograft Vasculopathy in Heart Transplant Recipients
The pathogenesis of cardiac allograft vasculopathy (CAV) in long-term survivors after heart transplantation (HTX) remains controversial. Histologically, CAV is characterized by intimal hyperplasia of the coronary arteries. Evidence suggests that hypercoagulability might play a role in CAV pathogenesis. Tetranectin (TN) is a homotrimeric C-type lectin, which is involved in the activation of tissue plasminogen activator and hepatocyte growth factor. Whether TN is associated with CAV pathogenesis, is unknown. Peripheral blood samples were obtained from 70 HTX patients and CAV was diagnosed in 35 recipients by coronary angiography and intravascular ultrasound. Mixed serum samples were then analyzed using a protein array, which indicated downregulated circulating TN levels in CAV versus no-CAV patients (p<0.0001). Subsequently, serum TN concentrations were determined by ELISA and were lower in CAV compared to no-CAV (p<0.01). Logistic regression analysis revealed that serum TN levels could diagnose CAV (OR=0.91; p<0.03). These results suggest that diminished TN levels are associated with CAV. Serum TN concentration could serve as a specific, easy to measure, quick and non-invasive marker in CAV diagnosis and monitoring.
- © 2011 by American Heart Association, Inc.