Abstract 12546: Different Neointimal Response to Overlapping Segments Between Everolimus- Eluting Stents and Sirolimus- Eluting Stents -Optical Coherence Tomographic Study
Background: Although overlapping coronary stents in long lesions by percutaneous coronary intervention are common, some recent clinical studies have revealed an adverse neointimal response to overlapping drug eluting stents due to increased drug and polymer toxicity. Thus, the purpose of this study was to evaluate the difference of neointimal response to overlapping everolimus- eluting stents (EES) and sirolimus-eluting stents (SES) by optical coherence tomography (OCT).
Methods: 35 consecutive lesions treated with overlapping stents (18 EES and 17 SES) were analyzed by OCT. We compared the OCT parameters including the rate of uncovered or malapposed struts, percentage neointimal hyperplasia (%NIH) and strut-level neointimal thickness between overlapping segments of EES and those of SES.
Results: A total of 2806 struts in 260 cross-sections of 35 stented segments were analyzed. At overlapping segments, the rate of uncovered or malapposed struts, %NIH and strut-level neointimal thickness in EES were significantly lower than those in SES (table).
Conclusions: According to our study assessed by OCT, EES showed more favorable neointimal response to the overlapping segments than SES. These findings should be considered when deploying overlapping stents in long lesions.
- © 2011 by American Heart Association, Inc.