Abstract 12294: Estimation of Pulmonary Arterial Pressure in Chronic Thromboembolic Pulmonary Hypertension Based on Interventricular Septal Configuration Obtained by Electrocardiogram-Gated 320 Slice CT
Purpose: We retrospectively determined whether the curvature of the interventricular septum measured by ECG-gated conventional scanning with 320-slice computed tomography (CT) was influenced by pulmonary artery (PA) pressure in subjects with chronic thromboembolic pulmonary hypertension (CTEPH).
Materials and Methods: Subjects (n=42, 59±12 yrs, 14 male) with proven CTEPH underwent right heart catheterization (RHC) and double volume retrospective ECG-gated enhanced conventional scanning using 320-slice CT (Aquilion ONE, Toshiba Medical) to obtain images of the whole heart, coronary arteries and pulmonary arteries. CT images were reconstructed every 5% from 0-95% of the R-R interval, and a series of short-axis images of the heart at the level of papillary muscle of left ventricle was acquired using double oblique multiplanar reformation (Zio Station). We compared septal bowing expressed as end-systolic curvature (reciprocal of radius [/cm], a leftward curvature was denoted as a negative value) with both systolic and mean pulmonary artery pressures (sPAP, mPAP).
Results: sPAP and mPAP from RHC were 71.8±20.6 mmHg and 41.4±11.7 mmHg, respectively. The correlation coefficients of septal curvature with sPAP and mPAP were −0.74 (P<0.001) and −0.81 (P<0.001), respectively.
Conclusions: Septal curvature based on ECG-gated 320-slice CT can be used to accurately estimate sPAP and mPAP in subjects with CTEPH. This imaging modality can be used to detect thrombi in the pulmonary arteries as well as to evaluate hemodynamics in CTEPH subjects.
- © 2011 by American Heart Association, Inc.