Abstract 12293: Increase in Prevalence but Improved Outcome for Heart Failure with Preserved Ejection Fraction in the Last Decade
Background: Previous studies have suggested the prevalence of heart failure with preserved ejection fraction (HFPEF) increased over the past 10 years. However, little is known about the prevalence of HFPEF in Chinese population and whether the prognosis of this condition has changed over time. We performed a study to explore the trends in the prevalence of HFPEF among Chinese patients in Hong Kong and its outcome over a 9-year period.
Methods and Results: We studied all consecutive patients hospitalized for heart failure from 2001 to 2009. We classified patients as having either preserved or reduced ejection fraction. The type of heart failure, comorbidity and survival between heart failure patients enrolled in 2001-2005 (Cohort-1) and those enrolled in 2006-2009 (Cohort-2) were compared. A total of 1,713 patients with heart failure were studied over the 9-year period. Data on ejection fraction were available from 1,426 (83%) patients. Among them, 44% had a reduced ejection fraction (i.e. <50%) and 56% had a preserved ejection fraction (i.e. ≥50%). The proportion of patients who had HFPEF increased over time (50.6% in Cohort-1 vs. 57.6% in Cohort-2, p=0.02). Similarly, the prevalence of hypertension also increased significantly over time (57.1% in Cohort-1 vs. 65.0% in Cohort-2, p=0.04). Also, the proportion of patients with age >70 years was also higher in the Cohort-2 (74% vs. 79.6%, p=0.02). Kaplan-Meier analysis showed that one year survival of HFPEF improved over time (65.5% in Cohort-1 vs. 76.9% in Cohort-2, Log-rank χ2=10.4, p=0.001) (Figure), while heart failure re-hospitalization rate also decreased over time (58.0% in Cohort-1 vs. 33.3% in Cohort-2, p<0.001).
Conclusions: The prevalence of HFPEF increased over a 9-year period in Chinese population, which may be resulted from higher prevalence of elderly subjects and hypertension over time. Nonetheless, their mortality and heart failure re-hospitalization rate in the first year decreased over time.
- © 2011 by American Heart Association, Inc.