Abstract 12256: Deceleration Time of Early Diastolic Velocity by Tissue Doppler Velocity image: A Novel Index of Left Ventricular Diastolic Function
Purpose: This study aimed to examine the diagnostic utility of the deceleration time (DT) of early diastolic velocity of mitral annulus by tissue Doppler velocity image, a method for the assessment of left ventricular diastolic function.
Methods: Simultaneous right heart catheterization and Doppler echocardiography were performed to compare the pulmonary capillary wedge pressure (PCWP) and DT in 28 patients. Furthermore, in 210 patients, DT was used to predict B-type natriuretic peptide (BNP) and differentiate the stages of diastolic function, namely, normal, abnormal, pseudo-normal and restrictive. We excluded the patients with atrial fibrillation and mitral valvular disease and who undergone mitral valvular surgery. Color-coded tissue Doppler images were acquired at apical 4 chamber view, and DT of early diastolic velocity measured at mitral annulus were assessed. The BNP levels were examined on the day of echocardiography.
Results: DT is inversely proportional to PCWP (r=0.60, p=0.002) and has significant correlation with log BNP (r=−0.22, p<0.0001). With a cut-off value of DT of 80 ms, which was determined by receiver operating characteristic curve, the sensitivity and specificity of DT to detect more than 200 pg/ml BNP level were 81 and 82%, respectively. Furthermore, patients with pseudo-normal and restrictive pattern had significantly shortened DT than those with normal and abnormal pattern (83±25 vs. 99±24, p<0.0001).
Conclusions: DT of early diastolic velocity of mitral annulus is an efficient novel index of LV diastolic function. And therefore, a promising parameter detecting and differentiating stages of diastolic dysfunction.
- © 2011 by American Heart Association, Inc.