Abstract 12164: Association of A Fat-Derived Hormone Omentin with Coronary Artery Disease in Men
Background: Obesity is closely associated with an increased risk for cardiovascular morbidity and mortality. Omentin is a fat-derived hormone whose concentrations are reduced in obese individuals. Here, we investigated whether circulating omentin levels associates with the prevalence of coronary artery disease (CAD).
Methods: The consecutive 78 male subjects were enrolled from patients who underwent coronary angiography. Sixty one age-matched male subjects were selected from healthy volunteers who underwent a medical examination and served as controls. Plasma omentin levels were measured by enzyme-linked immunosorbent assay.
Results: Plasma levels of omentin correlated negatively with body mass index (BMI), systolic blood pressure, hemoglobin A1c and total cholesterol levels, and positively with HDL cholesterol level. Circulating omentin was independently associated with hemoglobin A1c and HDL cholesterol in a multiple regression analysis. Plasma levels of omentin were markedly lower in CAD patients than in control subjects (Figure). Multiple logistic regression analysis with BMI, systolic blood pressure, hemoglobin A1c, glucose, HDL cholesterol and omentin revealed that plasma omentin levels were independently correlated with CAD.
Conclusion: We show here that low plasma omentin levels are independently associated with CAD prevalence even after adjustment for the known CAD risk factors, suggesting that omentin may be a novel biomarker of CAD.
- © 2011 by American Heart Association, Inc.