Abstract 12142: Catheter Ablation Outcome in AF Patients with Metabolic Syndrome
Introduction: Different components of metabolic syndrome (MS) such as hypertension, diabetes, dyslipidemia and obesity are identified to be risk factors for atrial fibrillation (AF). This study aims to investigate the impact of MS on outcome of catheter ablation in AF in terms of recurrence and quality of life (QoL).
Method: In this prospective observational study, 1496 consecutively enrolled AF patients undergoing first or redo catheter ablation [155, 32% paroxysmal AF (PAF); 116, 24% persistent (PER); 213, 44% long-standing persistent (LSP)] were classified into, Group 1: with MS (n=485, 64±8 years, 77% male, LVEF 55±12) and Group 2: without MS (n=1011, 62±11 years, 72% male, LVEF 57±9). Follow-up event-recording and 7-day Holter monitorings were performed at 3, 6, 9 and 12 months to check AF recurrence. Medical Outcome Study Short Form (SF-36) was used to assess QoL at baseline and 12-month post-ablation.
Result: After 21±7 months follow-up, 189(39%) patients in group 1 and 319(32%) patients in group 2 had arrhythmia recurrence (p= 0.005). When stratified by AF type, non-paroxysmal (non-PAF) patients in group 1 had significantly higher failure compared to group 2 [150(46%) and 257(35%), p= 0.002); while no difference existed in PAF subgroup [39(25%) group 1, 62(22%) group 2, p=0.440]. Compared to group 2, group 1 had significantly lower baseline score in all SF-36 subscales. At follow-up, both mental component (MCS) (59.5, 65.2, p<0.001), and physical component (PCS) scores (64.6, 73.7, p <0.001) showed improvement in patients with MS (group 1), whereas only MCS (69.2, 73.2, p=0.036) was improved in group 2 (without MS).
Conclusion: After a single procedure, the presence of MS was associated with significantly higher recurrence rate in non-paroxysmal AF (PER + LSP) only. More impairment in baseline QoL and higher improvement in follow-up assessment were observed in patients presenting with MS.
- © 2011 by American Heart Association, Inc.