Abstract 12112: Coffee Blunts the Acute Effect of Caffeine on Aortic Stiffness and Wave Reflections After Two Weeks of Daily Consumption
Objective: Both coffee and caffeine have an acute effect on arterial stiffness; however their acute-on-chronic effect has not been investigated.
Methods: The acute-on-chronic effect of a 2-week long, daily coffee or caffeine was studied in 11 healthy volunteers receiving on 4 separate occasions: a) triple espresso, b) decaffeinated triple espresso, c) 240mg of caffeine alone (amount contained in a triple espresso) and d) placebo. Repeated measurements were taken 30, 60, 90, 120 and 150 min. after drug administration at the first day (acute study) and at the end of each treatment arm (acute-on-chronic study). Aortic stiffness was evaluated with carotid-femoral pulse wave velocity (PWV) and wave reflections with augmentation index (AIx) of the aortic pressure waveform.
Results: PWV and AIx did not change after the 2-week long daily consumption of either coffee or decaffeinated coffee whereas, caffeine significantly increased both PWV and AIx (maximal responses by 0.51 m/sec and 4.3%, respectively, p<0.05 at the end of the treatment arm). The acute and acute-on-chronic effect of decaffeinated coffee on arterial stiffness was not significant. Coffee with caffeine induced a significant change in PWV and AIx values at the first day, however, the acute-on-chronic effect was proportionally less significant (upper panel). On the contrary there were not differences in PWV and AIx responses by caffeine between the acute and acute-on-chronic study(lower panel).
Conclusion: Coffee consumption has a less potent acute-on-chronic effect on aortic stiffness and wave reflections than caffeine. This finding indicates that substances other caffeine may partially counterbalance the active effect of caffeine on the intrinsic properties of the elastic arteries already modified by a two-week daily coffee administration.
- © 2011 by American Heart Association, Inc.