Abstract 12097: Resting Supine Heart Rate and Risk of Incident Heart Failure and All-Cause Mortality in 5475 Community-Dwelling Older Adults During 13 Years of Follow-Up
Background A high heart rate (HR) has been shown to be associated with poor outcomes in patients with heart failure (HF). However, the association of resting HR with outcomes in community-dwelling older adults is less well studied.
Methods Of the 5745 community-dwelling older adults, age ≥65 years, with data on baseline resting supine HR, in the public-use copy of the Cardiovascular Health Study data obtained from the NHLBI, 5475 were free of prevalent HF at baseline. Participants were categorized into quartiles of heart rate: <60 (reference), 60-66, 66-71, and ≥72 beats per minute (bpm).
Results Patients had a mean (±SD) age of 73 (±6) years; 58% were women; and 15% were African American. Unadjusted, age-sex-race-adjusted and multivariable-adjusted associations of the 3 higher heart rate quartiles with incident HF and all-cause mortality during over 13 years of follow-up are displayed in the Table. These associations remained unchanged among 4770 participants not receiving beta-blockers, among 4507 without coronary artery disease, and 5359 without atrial fibrillation. Among the 701 participants receiving beta-blockers, HRs (95% CI) for incident HF and all-cause mortality associated with heart rate ≥72 bpm were 1.44 (0.91-2.28; p=0.116) and 1.58 (1.12-2.23; p=0.009), respectively.
Conclusions Among community-dwelling older adults, a baseline resting supine heart rate of ≥72 bpm was associated with a significant independent increased risk of incident HF and all-cause mortality.
- © 2011 by American Heart Association, Inc.