Abstract 12072: The Association of Thromboembolic Complications and Blood Group in Patients with Atrial Fibrillation
BACKGROUND. Elevated Von Willebrand Factor (VWF) levels are associated with an increased risk of stroke in atrial fibrillation (AF). Individuals with blood group O are known to have 20-30% lower VWF levels due to altered hepatic glycosylation relative to individuals with other blood groups. To determine whether blood type influences the risk of thromboembolic complications, AF patients with blood group O were compared to those with other blood groups.
METHODS. The Mayo Clinic electronic medical record was queried to identify all patients with AF (2004 - 2010). Patients without blood group assessment were excluded. Records were analyzed for blood group, cerebrovascular accident, transient ischemic attack, cerebral embolism, peripheral embolism, and hemorrhagic stroke. All events were adjusted for CHADS2 score.
RESULTS. Over this time interval, 14,462 patients with AF and blood group confirmation were identified (Table). Cardioembolic event rates were lower for patients with blood group O (n=6055) compared to other blood groups (n=8407) after adjustment for CHADS2 (OR 0.82, 95% CI 0.68 - 0.99; p=0.037). This difference was primarily due to peripheral embolism rates, which were significantly lower in blood group O patients (OR 0.69, 95% CI 0.55 - 0.86; p=0.001).
CONCLUSION. Blood group O is protective against peripheral cardioembolic complications of AF, which may relate in part to reduced circulating VWF levels.
- © 2011 by American Heart Association, Inc.