Abstract 12069: Deceleration Capacity is a Powerful Predictor of Overall Mortality in Patients with Non-Ischemic Dilated Cardiomyopathy
Introduction: Deceleration Capacity (DC), a surrogate parameter of tonic vagal modulation of the heart rate, is a prognostic parameter in patients surviving acute myocardial infarction as shown in recent studies. However the use of this new Holter derived parameter of heart rate variety in patients suffering from non-ischemic dilated cardiomyopathy (DCM) has not yet been examined.
Hypothesis: We assessed the hypothesis that patients with non ischemic DCM and impaired DC have a higher long time mortality unaffected by left ventricular ejection fraction (LVEF).
Methods and Results: Holter-ECG recordings of 228 Patients treated in the years from 2000 until 2006 for non-ischemic DCM in the Hospital of the University of Luebeck, were retrospectively analyzed by the method of phase-rectified-signal-averaging (PRSA) to obtain DC. A total of 59 Patients died during the follow up of not less than 40 month. Kaplan Meyer Analysis showed a significantly higher mortality in patients with a DC below 4.5 ms (log rank p=0.012, Figure 1). Furthermore there was a higher mortality in patients with a DC below 4.5 ms and preserved LVEF (log rank p=0.014, Figure 2)
Conclusion: In conclusion it can be stated that DC is able to give information about overall mortality of patients with non-ischemic DCM regardless of LVEF. Thus making DC a valuable supplement to classical methods of mortality risk prediction in this group of patients.
- © 2011 by American Heart Association, Inc.