Abstract 11998: Systolic and Diastolic Left Ventricular Function are Important Determinants of Exercise Capacity in Diabetics Participating in Cardiac Rehabilitation
Background: Diabetics have a poorer prognosis than non-diabetics after myocardial infarction and exercise may reduce their mortality. Exercise tolerance is predicted by diastolic dysfunction in non-diabetics. The role of left ventricular (LV) function as a predictor of exercise capacity in diabetics participating in cardiac rehabilitation (CR) is unclear.
Hypotheses: Diabetics benefit from CR and their exercise performance is related to LV function.
Methods: A total of 948 patients (269 diabetics) were enrolled in a 12 week CR program. Risk factors, moderate level aerobic exercise capacity, and LV function were measured. Changes in values after CR (Δ) were evaluated. Peak METs represent the maximum obtained with moderate intensity exercise.
Findings: Overall, risk factors and exercise capacity improved in diabetics and non-diabetics (see table 1 and figure). In a multivariable analysis including age, gender, weight, and LV function, abnormal diastolic function was associated with a lower exercise tolerance (see table 2) in all patients.
Conclusion: In both diabetics and non-diabetics, abnormal diastolic function predicts a poorer improvement in exercise capacity. Furthermore, in diabetics, even with normal systolic and diastolic function, improvement was less than in non-diabetics suggesting an additional non-cardiac contribution to their poorer exercise intolerance.
- © 2011 by American Heart Association, Inc.