Abstract 11974: Associations Between Arterial Stiffness, Endothelial Function, and Ocular Involvement in Sarcoidosis
Background: Sarcoidosis (Sar) is a multisystemic inflammatory disease. It has been shown that Sar patients have impaired endothelial function, and increased arterial stiffness. Ocular involvement occurs in 15-25% of Sar patients mainly in the form of uveitis. The study was designed to determine if ocular involvement in Sar is associated with an extensive vascular dysfunction.
Methods: We enrolled 61 Sar patients and 61, age and sex matched, control subjects (Cl). Sar patients were divided in those with ocular Sarcoidosis (OS) (21 patients) and in those without ocular Sarcoidosis (WOS) 39 patients. Endothelial function was evaluated by flow-mediated dilatation (FMD). Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness and augmentation index (AIx) as a measure of arterial wave reflections.
Results: Although there was no significant difference in sex, age and mean arterial pressure ANOVA revealed that patients with OS compared to WOS patients and Cl subjects had impaired FMD (5.85±2.42% vs. 6.46±1.93% vs. 8.30±3.47%, p<0.001), increased AIx (24.00±9.19% vs. 17.99±10.99% vs. 13.76±10.76%, p<0.001) and increased PWV (8.29±2.42 m/sec vs. 7.00±1.12m/sec vs. 6.85±1.51 m/sec, p<0.005). More precisely, post hoc analysis revealed that patients with OS compared to WOS patients had significantly increased PWV (8.29±2.42 m/sec vs. 7.00±1.12m/sec, p=0.016). Moreover, AIx in OS patients was significantly increased compared to control (24.00±9.19% vs. 13.76±10.76%, p=0.002), although there was no difference between WOS patients and control subjects (17.99±10.99% vs. 13.76±10.76%, p=0.158).
Conclusion: In the present study we have shown that Sar patients with ocular involvement have impaired endothelial function and increased arterial stiffness. These results strengthens the vascular theory considers uveitis a consequence of vascular dysfunction in Sar patients.
- © 2011 by American Heart Association, Inc.