Abstract 11796: Determination of Regional Myocardial Performance in Hypertensive Patients with/without Left Ventricular Hypertrophy
Background: Quantitative imaging analyses showed an earlier septal wall involvement (J Hum Hypertens 2010) in hypertension (HT). We reported that regional septal dynamics relates to blood flow velocities (J Am Coll Cardiol 2011;57:2000, doi:10.1016/S0735-1097(11)62000-7). In this study, we determined the effect of HT on regional myocardial performance index (MPI) in a large population.
Methods: We evaluated 119 HT patients who were divided into gr. I: 57 HT without left ventricular hypertrophy (LVH), (53 ± 10,5 years), and gr. II: 62 HT with LVH (55 ± 1 years) using conventional and tissue Doppler imaging. They were compared with gr. III, a sex-age-matched control group (37 persons, 53 ± 0,8 years). We measured basal septal (figure 1) and basal lateral contraction time (CT), isovolumetric CT and isovolumetric relaxation time (IVRT) and calculated MPI.
Results: LV EF was 68 ± 5 % in gr. I, 69 ± 5 % in gr. II, 69 ± 4 % in gr. III. LV mass index was 122 ± 11 g/m2 in gr. I, 148 ± 13 g/m2 in gr. II and 118 ± 13 g/m2 in gr. III. Concentric LVH was detected in gr. II (relative wall thickness= 0,63 ± 0,08). LV septal and lateral MPI were abnormal in both HT groups (see table). IVRT and MPI were more severely abnormal in the septal wall compared with those in the lateral wall in gr. II (p=0.0001). Septal and lateral MPI was correlated with septal wall thickness (figure 2).
Conclusions: LV diastolic dysfunction exists in HT and becomes more severe in septal wall than lateral wall in LVH. MPI is abnormal in both LV walls in LVH and septal performance is more prominently affected by longstanding HT possibly due to earlier involvement in LV remodeling. Regional MPI values positively correlates to septal wall thickness.
- © 2011 by American Heart Association, Inc.