Abstract 11754: Resistin, Adipsin, Leptin, Total Adiponectin, and the Risk of Ischaemic Stroke in Healthy Middle-Aged Men: The Prime Study
Objective: To investigate associations and predictive properties of four plasma adipocytokines, namely resistin, adipsin, leptin, and total adiponectin with regard to incident ischaemic stroke in the PRIME Study.
Methods: A cohort of 9,771 healthy men 50 to 59 years of age at baseline was followed up over a period of 10 years. In a nested case-control study, 95 incident cases of ischaemic stroke were matched with 190 controls on age, study centre, and date of examination. Hazard ratios (HR) per standard deviation increase in plasma adipocytokine levels were estimated using conditional logistic regression analysis. The additive value of adipocytokines in stroke risk prediction was evaluated by discrimination and reclassification metrics and internally evaluated by bootstrapping.
Results: Resistin (HR 1.88, 95% CI 1.16-3.03), adipsin (HR 2.01, 95% CI 1.33-3.04), and total adiponectin (HR 1.53, 95% CI 1.01-2.34) but not leptin were independent predictors of ischaemic stroke. The performance of a traditional risk factor model predicting ischaemic stroke was significantly improved by the simultaneous inclusion of resistin, adipsin, and total adiponectin [c-statistic: 0.673 (95% CI 0.633-0.759) vs. 0.826 (95% CI 0.783-0.885), p<0.001; net reclassification improvement: 38.1%, p<0.001].
Conclusion: Increased plasma levels of resistin, adipsin, and total adiponectin were associated with a higher 10-year risk of ischaemic stroke among healthy middle-aged men. Resistin, adipsin, and total adiponectin provided incremental value over traditional risk factors in predicting ischaemic stroke risk.
- © 2011 by American Heart Association, Inc.