Abstract 11603: Late Diastolic Mitral Annular Velocity Predicts Long-Term Prognosis in Patients with Myocardial Infarction and Elevated Left Ventricular Filling Pressure
Background: Previous studies consistently demonstrated that the ratio of the early transmitral flow velocity (E) and the early mitral annular velocity (e') or E/e' predicts prognosis in patients with heart diseases. Although previous studies demonstrated that myocardial infarction (MI) patients with E/e' > 15, or elevated left ventricular (LV) filling pressure, have poor prognosis, prognostic impact of the late mitral annular velocity (a') in this high risk MI patients is unknown.
Objective: The aim of this study was to investigate prognostic impact of a' in high risk MI patients with elevated LV filling pressure.
Methods: A total of 723 MI patients with echocardiographic examination were enrolled. Patients with E/e' > 15 (n=237) were selected as high risk MI patients. Cardiac event was defined as a composite of death and hospitalization due to congestive heart failure.
Results During follow-up, cardiac event was documented in 45 patients (19%). Patients were grouped according to the median value of a', high a' group (a' > 6.88 cm/s) and low a' group (a' <= 6.88 cm/s). Low a' group showed significantly lower event-free survival than high a' group (Figure, Log-rank P=0.007).
Conclusion: In high risk MI patients with elevated LV filling pressure, late diastolic mitral annular velocity was related to long-term prognosis.
- © 2011 by American Heart Association, Inc.