Abstract 11553: A New Method to Estimate Aortic Pulse Wave Velocity and Central Systolic Blood Pressure by Measuring Brachial Cuff Pulse Waveform
Objectives: Measuring not only brachial blood pressure but central blood pressure has been shown to be valid in assessing the risk of a cardiovascular event and evaluating drug efficacy. We developed a new method to estimate aortic pulse wave velocity (aPWV) and central systolic blood pressure (cSBP) by measuring only brachial cuff pulse waveform in a simplified manner over a short period of time, enabling usage not only in clinics but also in homes. The primary aim of this study was to evaluate accuracy and reproducibility of this new method.
Methods: In 99 healthy control subjects (aged 48.3±16.9) and 104 patients with coronary artery disease (aged 64.6±11.1), brachial pulse waveform was measured using cuff (Central Blood Pressure Monitor, Omron Healthcare Co.,Ltd.). Central Blood Pressure Monitor estimated aPWV and cSBP from brachial pulse waveform measured with cuff at supra systolic blood pressure. cSBP was calculated by processing waveform with a filter parameterized by blood pressure, height and age. Also, aPWV was estimated by separating forward wave and reflection wave from the filtered waveform. To assess accuracy, in all subjects, the aPWV measurement was compared against heart-to-femoral pulse wave velocity (hfPWV) by sensors on heart and femoral artery. Also, in control subjects, the cSBP measurement was compared against measurement by an applanation tonometry-based method. Moreover, to assess reproducibility, in control subjects, consecutive measurements of aPWV and cSBP were compared.
Results: aPWV by brachial pulse waveform measurement correlated to hfPWV (controls r=0.79, patients r=0.62; both groups P<0.001). cSBP has shown strong correlation with tonometry-based method (r=0.90, P<0.001). Measurement reproducibility was 6.3±43.6cm/s in aPWV, 6.2±65.3cm/s in hfPWV and 2.4±4.8mmHg in cSBP.
Conclusions: These results suggest that aPWV and cSBP can be estimated from brachial pulse waveform with cuff in a simplified manner.
- © 2011 by American Heart Association, Inc.