Abstract 11525: Physical Activity and Incident Heart Failure in Community Dwelling Older Adults with and without Metabolic Syndrome
Background: Physical activity (PA) has previously been shown to be associated with lower risk of incident heart failure (HF). Its effects may be more pronounced in metabolic syndrome (MetS) subjects, as it may counteract each of the constituent risk factors. In the current analysis, we used public-use copy of the Cardiovascular Health Study data obtained from the National Heart, Lung and Blood Institute to examine the association of PA with incident HF in participants with and without MetS.
Methods: Of the 5775 community-dwelling adults ≥65 years with data on self-reported baseline kilocalories of energy expended per week, 5485 were free of HF at baseline. Of them 2470 (50%) had MetS defined using Adult Treatment Panel (ATP) III criteria. Participants were categorized into 4 PA groups based on metabolic equivalent minutes a week (MET-min/wk): inactive (0), and low (0-499), medium (500-999) and high (≥1000) PA.
Results: Patients (n=5775) had a mean (±SD) age of 73 (±6) years; 58% were women; and 15% were African American. Unadjusted, age-sex-race-adjusted and multivariable-adjusted associations of 3 levels of PA (vs. inactive) with incident HF during over 13 years of follow-up, separately among those with and without MetS, are displayed in the Table. Without MetS, level of PA had no association with incident HF. However, with MetS, all levels of PA had unadjusted association, and high PA had an independent association with lower HF risk.
Conclusions: Among older adults with MetS, higher levels of PA were independently associated with lower risk of incident HF, but an independent association was not observed among those without MetS. Public health measures to encourage physical activity, like promoting 300 minutes moderate PA per week, particularly among older adults with MetS, may help to lower the risk of incident HF.
- © 2011 by American Heart Association, Inc.