Abstract 11373: Short Term Vitamin D Treatment Inhibits the Increase in Inflammatory Cytokine and Adhesion Molecule Levels in Patients After a Coronary Event
Introduction: Low vitamin D levels are associated with a higher prevalence of cardiovascular risk factors and a higher risk of myocardial infarction. Vitamin D has immune modulating properties. In this paper we examine the effects of short vitamin D treatment, after an acute coronary syndrome, on inflammatory cytokines and vascular adhesion molecule levels.
Methods: Patients were recruited after presenting with an ACS. All patients received optimal medical therapy and underwent a coronary angiography. Half of the patients were treated with oral vitamin D, 4000 units per day for 5 days. Circulating levels of vitamin D, VCAM-1, ICAM-1, E-Selectin, VEGF, CRP, IL-6, IL-8 and TNF were tested upon arrival and after 5 days.
Results: Fifty patients were recruited. Average patient age was 60; thirty-nine patients were male. Average vitamin D levels were 18.5ng/mL. In the control group there was an increase in inflammatory cytokine levels after five days. Treatment group cytokine levels showed a decreased elevation or a reduction compared to the control (Table 1). There were significant differences in VCAM-1 levels (decrease of 15.36 ng/mL vs. increase of 103.03 ng/mL, P=0.0011) and IL-6 (-0.11 pg/mL vs. 3.33 pg/mL, P=0.0005). There were trends towards significance in levels of ICAM-1 (-1.26 vs. 19.97 ng/mL, P=0.17), CRP (1.3 vs. 3.25 mg/dL, P=0.09), E-Selectin (-4.14 vs. -0.15 ng/mL, P=0.16), VEGF (137.4 vs. 263.1 pg/mL, P=0.16), IL-8 (-6.36 Vs. 7.95 pg/nL, P=0.1). There was no meaningful difference in TNF levels.
Conclusion: A short treatment with vitamin D effectively inhibits the increase in circulating levels of inflammatory cytokines and vascular adhesion molecules after an acute coronary event. These findings shed a light on the anti-inflammatory effects of vitamin D on the vascular system, and may explain some of its cardio-protective properties. There is place for further studies involving prolonged vitamin D treatment in patients suffering from ischemic heart disease.
- © 2011 by American Heart Association, Inc.