Abstract 11221: Safety and Efficacy of Exercise Training After Coronary Stenting in Patients with Stable Coronary Artery Disease
Background: Exercise training (ET) after coronary stenting is considered to have a risk of stent thrombosis (ST). However, little is known about the impact of ET on ST. We investigated whether ET increases the incidence of ST in patients undergoing coronary stenting.
Methods and Results: This study was a prospective observational study. We enrolled 3672 patients who underwent successful coronary stenting. Patients decided whether to participate in exercise and were divided into an ET group (n=1592) and a control group (n=2080). The ET was planned for three times per week with moderate exercise intensity based on Borg index. The follow-up period was 36 months. Primary endpoint was the incidence of ST. Secondary endpoints were major adverse cardiovascular events (MACE: death, myocardial infarction and stroke) and unscheduled hospital visits for worsening angina. The incidence of Stand MACE were similar in both groups (1.8% vs 2.0%, p=0.73, 14.9% vs 15.0%, p=0.97, respectively). Unscheduled hospital visits for worsening angina were significantly lower in the ET group than in the control group (20.2% vs 27.2%, p<0.0001). After adjusting for baselines, the ET group had no significant increase in the incidence of ST (hazard ratio [HR] 0.86, adjusted P=0.56) and MACE (HR 0.98, 95% CI 0.82 to 1.17, adjusted P=0.83). The ET was effective to prevent a unscheduled hospital visits for worsening angina (HR 0.67, adjusted P<0.0001).
Conclusion: Moderate ET after successful coronary stenting does not increase the incidence of ST and MACE, and was effective in reducing unscheduled hospital visits for worsening angina.
- © 2011 by American Heart Association, Inc.