Abstract 11207: Global Longitudinal Left Ventricular Strain Assessed by Speckle Tracking Imaging Is an Independent Strongest Predictor of Plasma BNP Levels in Patients with Cardiac Amyloidosis
Background: Cardiac amyloidosis is characterized by an early impairment in longitudinal left ventricular (LV) systolic function at a time when fractional shortening remains normal. We examined which parameter by speckle tracking echocardiography (global LV longitudinal/circumferential strain, and LV torsion) is mostly associated with plasma BNP levels in patients with cardiac amyloidosis.
Methods: We examined 312 consecutive patients with cardiac amyloidosis who underwent standard echocardiographic, Doppler flow, and 2 dimensional speckle tracking imaging examinations. Plasma BNP levels were measured on the day of echocardiography. Global longitudinal LV strain was obtained from apical 3 views by automatic functional imaging and global circumferential LV strains and LV torsion were measured in parasternal short axis views at basal, mid and apical LV levels (GE Echo Pac PC).
Results: Univariate and multivariate analyses showed that the global longitudinal strain by automatic functional imaging was the most powerful and independent predictor of plasma BNP levels (R=0.699, P<0.0001) among standard echocardiographic, Doppler flow, and 2 dimensional speckle tracking parameters.
Conclusions: Global longitudinal LV strain rather than global circumferential strain and LV torsion is associated with elevated plasma BNP levels in patients with cardiac amyloidosis. Measurement of plasma BNP levels is useful for presuming the global longitudinal LV strain in patients with cardiac amyloidosis.
- © 2011 by American Heart Association, Inc.