Abstract 11173: Contribution of Blood Inflammatory Proteins to Depression in Patients undergoing Coronary Artery Bypass Surgery: A Single- Center Prospective Study
Background: Depression is a common feature observed in patients with coronary heart disease, and is associated with inflammatory response. However, the effects of blood inflammatory proteins on the risk for depression remains unclear in patients undergoing coronary artery bypass grafting (CABG).
Methods and Results: In this study, 232 consecutive patients undergoing elective CABG were evaluated for depression utilizing the 9-item Patient Health Questionnaire scale at baseline and 6 months following CABG. In addition, peripheral blood samples were collected at baseline, and the serum levels were measured for high sensitive C-reactive protein (hsCRP), intercellular adhesion molecule 1 (ICAM-1), interleukin-1β (IL-1β) and interferon-γ (IFN-γ). The pre-operative and post-operative rate of depression was 18.1%. Interestingly, pre-operative depression was independently associated with females (odds ratio [OR] 2.37, 95% confidence interval [CI] 1.06, 5.33) and hsCRP (OR 1.16, 95% CI: 1.06, 1.27) after adjusting for various factors using logistic regression, including age, sex, education, medical expense burden, etc. Postoperative depression was only associated with hsCRP (OR 1.15, 95% CI: 1.05, 1.25) in these patients. Likewise, elevated hsCRP levels (OR 1.16, 95% CI 1.05, 1.28) remained associated with future depression during a follow-up questionnaire, and were independent of post-operative medications and major adverse cardiovascular events.
Conclusions: The present study is the first to report elevated serum hsCRP as an independent predictor for depression in CABG patients both pre-operatively and up to 6 months after surgery. Furthermore, these findings also suggest that inflammation may contribute to depression in CABG patients.
- © 2011 by American Heart Association, Inc.