Abstract 11118: Evaluation of Right Ventricular Systolic and Diastolic Function and Prognosis Using Tissue Doppler and Speckle-Tracking Imaging in Patients with Primary Pulmonary Hypertension
OBJECTIVE: In patients with primary pulmonary hypertension (PPH), right ventricular (RV) pressure overload causes right heart failure. We sought to investigate the severity of RV systolic and diastolic dysfunction and prognosis using tissue Doppler (TDI) and speckle-tracking imaging (STI).
METHODS: We performed TDI and STI in 46 PPH patents. We measured early diastolic peak velocities of tricuspid inflow (TE), peak systolic (Ts') and early diastolic tricuspid annular velocities (Te') by TDI. RV peak systolic strain (PS), RV peak systolic strain rate (SSR), and RV peak early diastolic strain rate (DSR) were analyzed by STI in the longitudinal direction. Right atrial pressure (RAP) and cardiac index (CI) by right heart catheterization, and serum brain natriuretic peptide (BNP) were measured.
RESULTS: There were significant correlations between CI and Ts'(r=0.57, p<0.01), TE/Te' (r=0.72, <0.01), PS (r=0.63, <0.01), and SSR (r=0.45, p<0.01). There was significant correlation between RAP and TE/Te' (r=0.72, p<0.01), and PS (r=0.40, <0.01). BNP level was correlated with TE/Te'(r=0.72, p<0.01), PS (r=0.67, <0.01), SSR (r=0.64, p<0.01), Ts'(r=0.55, p<0.01). Six patients died within one year. TE/Te' (odds ratio 3.10, p=0.01) was independent predictor to evaluate the prognosis.
CONCLUSIONS: TDI and STI were useful for noninvasive evaluation of RV dysfunction and prognosis in patients with PPH.
- © 2011 by American Heart Association, Inc.