Abstract 11080: Relation of Changes in Coronary Artery Calcium, Bone Mineral Density Measured Computed Tomography and Aged Garlic Extract
Background: We recently reported that lower levels of bone mineral density (BMD) is associated with the severity of subclinical atherosclerosis measured by coronary artery calcium (CAC). The current study evaluates the beneficial effects of aged garlic extract therapy with supplements (AGE+S) on levels of BMD and CAC.
Methods: In this placebo-controlled, double-blind, randomized trial, 60 intermediate risk subjects (age 60±9 years, 79% male) underwent CAC, and thoracic BMD measurement at baseline and 12 months. A capsule of placebo or aged garlic extract (250 mg), Vitamin B12 (100μg), Folic Acid (300μg), Vitamin B6 (12.5mg) and L-Arginine (100mg) was given daily for 1-year. Trabecular-BMD(mg/cc) of four consecutive thoracic-vertebrae below the left-main coronary artery slice-level was assessed. CAC progression was defined as annual increase in CAC>15%. Reduced BMD was defined as median annual decrease of 6 mg/cc in BMD.
Results: At baseline, there were no significant differences in cardiovascular risk factors, age, gender, CAC and BMD among cohorts. (P>0.05) From baseline to 12 months, a significant correlation was noted between increase in CAC and decreases in BMD (r=0.75, r2=0.52, p=0.0001). At 1 year, the mean increase in CAC and decrease in BMD was significantly lower in the AGE+S as compared to the placebo group (p<0.05). After adjustment of conventional risk factors using logistic regression, the risk of CAC progression and reduced BMD was 65% and 68% less in AGE+S as compared to placebo cohort(P<0.05).
Conclusion: This study documents: 1) a significant association between progression of CAC and reduction in BMD levels, and 2) AGE+S is associated with favorable effects on reducing the progression of subclinical atherosclerosis and loss of BMD.
- © 2011 by American Heart Association, Inc.