Abstract 11066: Long Term Clinical Outcome and Response to Statin Therapy of Veterans with Posttraumatic Stress Disorder
Background: We recently reported that posttraumatic stress disorder (PTSD) is independently associated with the presence and severity of subclinical coronary artery disease (CAD) within the Veterans population. This study investigates the sex-specific long-term clinical outcome and response to statin therapy in Veterans with PTSD.
Methods: Electronic medical records were used to assess diagnoses, survival and pharmacotherapy from Southern California and Nevada veterans. The sex-specific relative risk (RR) of mortality was calculated using generalized estimating equation analyses.
Results: The study population consisted of 287,013 veterans [age 65+_14 years, 40,966(14.2%) women. During a median 130-month follow-up, PTSD was more prevalent in male (n=29505 (11.9%)) than female (n=995 (2.3%)) Veterans. The mortality risk of PTSD was significantly higher in women as compared to men, especially with the presence of coronary artery disease (p<0.05)(Table).Survival rate in PTSD patients with and without statin therapy was 89% and 78%, respectively p=0.0001). Statin therapy was associated with 68% and 47% mortality risk reduction in male and female Veterans with PTSD, respectively (p<0.01). (Figure)
Conclusion: 1) PTSD is associated with CAD and mortality in both genders and 2) Statin therapy is associated with significantly improved survival rate in PTSD patients.
- © 2011 by American Heart Association, Inc.