Abstract 11064: Bone Mineral Density is Inversely Related with Coronary Artery Calcification Independent of Age, Gender and Ethnicity
Background: Osteoporosis and atherosclerosis are major public health problems that often coexist in both genders worldwide. Coronary artery calcium(CAC) is an anatomic marker of the burden of atherosclerosis and correlates with the presence and extent of coronary disease(CAD). While prior work has indicated negative correlations between CAC with thoracic bone mineral density(BMD), it remains unclear if this is independent of age, gender and ethnicity.
Methods: Five thousand five hundred and ninety consecutive asymptomatic subjects(mean age 57±12, 69% male) underwent CAC scanning and their thoracic BMD were measured using non-enhanced computed tomography. Trabecular-BMD(mg/cc) of four consecutive thoracic-vertebrae below the left-main coronary artery slice-level was assessed. Subjects were classified based on their CAC Agatston-score(AJ) to CAC 0, 1-100, 101-400 and 400+.
Results: The levels of BMD were significantly lower with the presence and severity of CAC in both genders, and remained significant after adjustment for risk-factors. The mean increase in CAC with each 10 mg/cc lowering in the levels of BMD was 19 AJ in men, and 21 AJ in women, and was more in postmenopausal women as compares to premenopausal women(59 vs. 20 AJ)(P<0.05). The risk of each standard-deviation decreased in the levels of BMD was 1.22, 2.21 and 3.44 in Caucasians with CAC 1-100, 100-400 and 400+ as compared to CAC 0, respectively. Similar associations were observed across Asian, Hispanics and African Americans(P<0.05).
Conclusions: Lower levels of BMD are associated with the higher severity of subclinical-atherosclerosis as measured by CAC independent of age, risk factors in both genders across multi-ethnicity.
- © 2011 by American Heart Association, Inc.