Abstract 10966: High Cardiorespiratory Fitness Attenuates the Age-Related Increase in Pulse Wave Velocity in Apparently Healthy Men
High levels of cardiorespiratory fitness (fitness) provide a strong protective effect against age related cardiovascular disease mortality, but the underlying mechanisms are not fully understood. Subclinical atherosclerosis/target organ damage, assessed as pulse wave velocity (PWV) and carotid intima media thickness (IMT), increases with advancing age and are associated with increased risk of cardiovascular events and mortality. We evaluated whether high fitness attenuates the age related increases in PWV and IMT.
Methods. We measured brachial ankle PWV and common carotid artery IMT using a volume plethysmographic apparatus and B-mode ultrasound, respectively in 4017 apparently healthy men (mean age 49±7yrs). Fitness was measured by peak oxygen uptake using expired gas analysis during maximal treadmill testing. Participants were divided into three group based on age: young (<45 yr), middle aged (45-55yr), and older groups (>55yr). Fitness categories were classified as low fit (<20%), moderate fit (20-60%), and high fit (>60%) based on age-specific peak oxygen uptake percentiles.
Results. According to two way ANCOVA, there was a significant interaction effect between age group and fitness group for PWV (P<0.05), but not IMT (adjusted for BMI, waist circumference, SBP, TC, HDL-C, glucose and WBC). PWV and IMT were significantly lower in the high fit group than in the low fit group (p<0.05 for all) in all age groups. There was a significant correlation between fitness and PWV (r=-0.26, p<0.01) and IMT (r=-0.25, p<0.01) in all participants and specifically within the older group (PWV, r=-0.34, p<0.01); IMT, r=-0.12, p<0.01).
Conclusions. These results demonstrate that high cardiorespiratory fitness is inversely associated with PWV and IMT. Age-related increases in PWV are attenuated by high cardiorespiratory fitness.
- © 2011 by American Heart Association, Inc.