Abstract 10934: Relation of Fibrillatory Wave Amplitude to Left Atrial Remodeling in Patients with Chronic Atrial Fibrillation
Background: The relationship between fibrillatory wave amplitude to left atrial anatomical remodeling has been examined by echocardiography. However, this relationship has yet not been examined by multidetector computed tomography (MDCT) with high-definition imaging. We examined this relationship by MDCT in patients with chronic atrial fibrillation.
Methods: Patients with chronic atrial fibrillation (n = 120, 96 men and 24 women, mean age of 61 years ± 8.3) who underwent MDCT were enrolled in the study. Measurements were performed on the latest atrial diastolic phase. Left atrial (LA) volume and diameter were measured. The mean LA myocardial wall thickness, which was an average of the wall thicknesses of the anterior, posterior, roof, and bottom of the LA, was also measured. Maximal amplitude of the fibrillatory wave was determined using computer-assisted calipers in V1 lead. The mean amplitude of the fibrillatory wave was calculated from 30 fibrillatory waves and compared to measurement data obtained by MDCT.
Results: There were significant negative correlations between the mean amplitude of the fibrillatory wave and LA diameter (r = −0.34; P = 0.01). There were also significant negative correlations between the mean amplitude of the fibrillatory wave and LA volume (r = −0.40; P = 0.01). Furthermore, there were significant positive correlations between the mean amplitude of the fibrillatory wave and mean LA myocardial wall thickness (r = 0.62; P < 0.0001).
Conclusion: The amplitude of the fibrillatory wave recorded by 12 lead ECG would be a useful marker of dilatation and wall thinning of the LA indicating remodeling progress.
- © 2011 by American Heart Association, Inc.