Abstract 10797: Association of Cardiovascular Risk Factors with Minimally Elevated Cardiac Troponin T Detected by a Novel Highly Sensitive Assay
Introduction Using a novel highly sensitive assay, minimally elevated cardiac troponin T (cTnT) levels were recently demonstrated to independently predict incident CV disease. We sought to characterize the determinants of minimally elevated cTnT in the general population.
Methods We examined the cross-sectional association between CV risk factors and cTnT in 9,593 participants free of CV disease from the community-based Atherosclerosis Risk in Communities (ARIC) Study. We used multivariable logistic regression models to characterize the association between CV risk factors and minimally elevated (≥3.0 to 13.9 ng/L) and elevated (∼90th %ile) (≥14.0 ng/L) cTnT.
Results cTnT levels were minimally elevated in 66% (6,312 participants) and elevated in 7% (665 participants) of the study population. Among persons at low 10-year CV risk (ARIC-CHD Risk Score <10%), cTnT was elevated in 8% and 13% of white and black men, and in 2% and 4% of white and black females, respectively. After adjustment for significant determinants of cTnT levels, minimally elevated cTnT was more common among males, persons with diabetes, hypertension and blacks and less common among statin users, current smokers and drinkers (Table). Other risk factors associated with minimally elevated cTnT were older age, lower kidney function and higher body mass index. These risk factors were associated with elevated cTnT in a similar pattern. Among persons with the metabolic syndrome, cTnT was minimally elevated in 59% and elevated in 9%. There were no persons with absent CV risk factors with elevated cTnT.
Conclusion In a community-based sample of persons without CV disease, minimally elevated levels of cTnT are detectable in most adults. Although most traditional CV risk factors were significant determinants of minimally elevated and elevated cTnT, the associations were particularly robust for male gender, diabetes and older age. On the other hand, no individuals with absent CV risk factors had elevated cTnT.
- © 2011 by American Heart Association, Inc.