Abstract 10775: Prevalence and Risk Factor Correlates of Descending Aortic Plaque in the Framingham Offspring Cohort: Comparison of Noncontrast Magnetic Resonance and Noncontrast Computed Tomography
Background: Descending aortic plaque (DAP) can be visualized by magnetic resonance (MR) imaging or by computed tomography (CT). MR mainly shows noncalcified plaque while noncontrast CT best depicts calcified plaques. We sought to determine the prevalence and risk factor (RF) correlates of thoracic and abdominal DAP detected by MR vs. CT in the Framingham Offspring cohort.
Methods: 1016 Offspring (64±9y, 474 men) underwent both MR (1.5T, T2W black-blood TSE) and CT (8-slice MDCT) of the descending aorta during 2002-2005. Prevalent DAP by MR was any luminal protrusion >= 1 mm; prevalent DAP by CT was an Agatston score > 0. Potential RFs for DAP (BMI, age, pulse pressure, LDL, HDL, fasting plasma glucose; sex, hypertension, diabetes, current smoking, use of antihypertensive (HTN Rx), diabetes or lipid-lowering (Chol Rx) drugs) were compared between participants with zero vs. nonzero DAP by MR and separately for DAP by CT. Candidate RFs attaining p<0.05 for difference by either MR or CT were entered into a logistic regression model adjusting for age, sex and other RFs; odds ratios (ORs) were calculated for imaging modality-specific prevalence of DAP.
Results: 115 (11.3%) participants had neither MR nor CT DAP, 72 (7.1%) had only MR DAP, 402 (39.6%) had only CT DAP, and 427 (42.0%) had both MR and CT DAP. Increasing age and current smoking status were associated with greater odds of DAP by both MR and CT. Increased LDL and use of HTN Rx or Chol Rx were associated with greater odds of CT DAP while HDL was inversely associated. Female sex, increased fasting plasma glucose and pulse pressure were associated with MR DAP while BMI was inversely associated. Statistically significant multivariable adjusted ORs are shown in the Table in bold.
Conclusions: Prevalent DAP by both MR and CT is associated with smoking and increasing age. MR-detected DAP was more prevalent with female sex, dysglycemia and pulse pressure, while prevalence of calcified (CT) DAP was greater with dyslipidemia, HTN Rx and Chol Rx.
- © 2011 by American Heart Association, Inc.