Abstract 10761: Ideal Cardiovascular Health and Development of Depressive Symptoms: The CARDIA Study
Introduction A favorable cardiovascular (CV) risk factor profile has been shown to have multiple benefits, including reduced risk for CV and non-CV mortality, improved quality-of-life, and reduced Medicare costs. Whether ideal CV health may protect against the development of depression has not been examined.
Hypothesis We hypothesize that ideal CV health confers a reduced risk for future depressive symptoms.
Methods We evaluated 2266 participants from the Year 5 CARDIA exam and defined ideal CV health as untreated cholesterol <200 mg/dL, untreated BP <120/80 mmHg, no history of smoking, no history of MI, BMI < 25 kg/m2, physical activity > 300 exercise units, and glucose < 100 mg/dL (or no self reported diabetes in the absence of glucose). Depressive symptoms were defined as a Center for Epidemiologic Studies Depression Scale score >= 16 or use of an antidepressant at the year 10, year 15 or year 20 exams. Participants with depressive symptoms or with a self-reported prior history of nervous, emotional or mental disorder at the year 5 exam were excluded from the analyses. Missing data were imputed prior to analyses using multiple imputation.
Results A total of 163/1087 men and 215/1179 women were in ideal CV health. After adjustment for age and race, ideal CV health was associated with a reduced odds of developing depressive symptoms at 2 or more visits versus 0 visits in men (odds ratio=0.36, 95% CI: 0.14-0.92) but not in women (Table). This association in men was slightly attenuated after further adjustment for alcohol intake and SES.
Conclusions In men free of depressive symptoms, having ideal CV health is associated with a reduced risk of developing subsequent repeated depressive symptoms.
- © 2011 by American Heart Association, Inc.