Abstract 10684: Prognostic Value of Late Gadolinium Enhancement in Patients with Non-Ischemic Cardiomyopathy
Background: Patients with non-ischemic cardiomyopathy (NICMP) are at increased risk for cardiovascular events and death. The presence of late gadolinium enhancement (LGE) in cardiac magnetic resonance (CMR) may be associated with a poor prognosis but its significance is still under investigation.
Methods: We retrospectively studied 114 consecutive pts with NICMP (LVEF ≤40%) referred for CMR. The cohort was analyzed for presence of LGE and LV and RV functional parameters. Multivariate logistic regression was used to evaluate different risk factors for the development of a composite endpoint of hospitalization for congestive heart failure (CHF), appropriate ICD therapy or all cause-mortality.
Results: LGE was observed in 68% (n = 78) of the cohort. Both groups were similar in age (50 ±15yrs vs 51± 14yrs; p=0.53), LVEF (25±9% vs 26±9; p=0.67), LV end-diastolic volume 291±105 ml vs 271±101 ml, p=0.31). At a mean follow-up of 777 days±574, there were 26 pts (23 in the LGE+ group) who reached the primary endpoint. Event free survival was significantly worse for the LGE+ patients (Figure). After adjusting for traditional risk factors (age, sex, and LVEF), patients with LGE reached the composite endpoint (odds ratio 5.1, 95% CI 1.2-21.2, p=0.024) more than those without LGE.
Conclusions: The presence of LGE in patients with NICMP strongly predicts the occurrence of adverse events. This may be important in risk stratification and management.
- © 2011 by American Heart Association, Inc.